Review: Multiple system atrophy: emerging targets for interventional therapies

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Review: Multiple system atrophy: emerging targets for interventional therapies

Multiple system atrophy (MSA) is a fatal orphan neurodegenerative disorder that manifests with rapidly progressive autonomic and motor dysfunction. The disease is characterized by the accumulation of α-synuclein fibrils in oligodendrocytes that form glial cytoplasmic inclusions, a neuropathological hallmark and central player in the pathogenesis of MSA. Here, we summarize the current knowledge ...

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ژورنال

عنوان ژورنال: Neuropathology and Applied Neurobiology

سال: 2016

ISSN: 0305-1846,1365-2990

DOI: 10.1111/nan.12304